A stochastic inventory model of COVID-19 and robust, real-time identification of carriers at large and infection rate via asymptotic lawsResearch article Published on 2023-01-012022-10-05 Journal: European Journal of Operational Research [Category] 변종, [키워드] affecting Asymptomatic asymptotic Care carrier COVID-19 COVID-19 incidence COVID-19 pandemic Critical data-driven deaths distribution Epidemic modeling Evolution fraction Health incidence infection rate Little's law management manifested Measures National Operations management under uncertainty OR in health services Outbreaks Patient Perspective profiles provide random Randomly reconstructed robust scaled Spread symptomatic carrier the disease the mean the SARS-CoV-2 trajectory variable variables [DOI] 10.1016/j.ejor.2021.12.037 [Article Type] Research article
A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate responseArticle Published on 2022-12-212022-11-15 Journal: Journal of theoretical biology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] adaptive alveolar alveolar cells antibodies antibody antibody concentration baseline Cell cell death Cellular automaton COVID-19 develop diffusion domain Efficacy Future Gas exchange healthy human lung Immune cell immune protection immune response Immunity infected cell Infection initial Innate innate immune Innate immunity innate response Interaction interferon interferons lung alveolar maintain manuscript mechanism Model multiple mechanism outcome Pneumonia produced profiles progression Result RNA copy SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant simulations. Spread Strains submitted switching T cells the SARS-CoV-2 virus two-dimensional type I Viral load virion virions [DOI] 10.1016/j.jtbi.2022.111293 PMC 바로가기
Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cellsArticle Published on 2022-11-022022-11-15 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] Antiviral antivirals approved drug caused clinical evaluation Combination Compound concentrations conducted COVID-19 drug Effect Efficacy epithelial cell line exonuclease global pandemic HCV hepatitis C human lung human lung cell identify inhibitor moderate morbidity Mortality NS5A pharmacokinetic profiles Protein Remdesivir SARS Coronavirus SARS-CoV-2 SARS-CoV-2 replication Support synergy the SARS-CoV-2 therapeutic treatment strategy virus [DOI] 10.1038/s41598-022-21034-5 PMC 바로가기
Immunogenicity and safety of two doses of SARS-CoV-2 mRNA vaccine in kidney transplant recipients with low-dose rituximabArticle Published on 2022-11-012022-11-15 Journal: International journal of urology : official journa [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome affected antibody antigen-specific T cell baseline cellular response Control controls coronavirus coronavirus disease COVID-19 demonstrated Deterioration dose enrolled enzyme-linked immunospot enzyme-linked immunospot assay evaluated healthcare worker healthy control humoral immunogenicity kidney Kidney function kidney transplant recipient kidney transplant recipients Kidney transplantation lack low-dose mRNA mRNA vaccine multivariate regression analysis not affect not significantly different profiles rituximab. SARS-CoV-2 Seroconversion seroconversion rate Spike protein systemic adverse event the vaccine treatment history vaccination Vaccine [DOI] 10.1111/iju.14978 PMC 바로가기
Extended coagulation profile of children with Long Covid: a prospective studyArticle Published on 2022-11-012022-11-16 Journal: Scientific Reports [Category] SARS, 치료기술, [키워드] activated acute SARS-CoV-2 infection Adults age analyzed Antigen Biomarker case-control study change characterized children Coagulation cofactor Cohort control group controls D-dimer level D-dimers Diagnosis eight endothelial damage endotheliopathy enrolled explained Extended females fibrinogen Follow-up FVIII Infection initial International IQR ISARIC Italy Long majority microbiologically no significant difference normalized pediatric plasma profile profiles proportion Prospective Study Prothrombin time respiratory Sample SARS-COV-2 infection Symptom Symptoms the median the SARS-CoV-2 von Willebrand factor vWF [DOI] 10.1038/s41598-022-23168-y PMC 바로가기
Advanced setup for safe breath sampling and patient monitoring under highly infectious conditions in the clinical environmentArticle Published on 2022-10-262022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, [키워드] Analysis being Biomarker breath caused Compound condition conditions contagious disease transmission Effects examined immediate effect Infection infection risk infectious condition intensive care Observed offer Patient physiological point-of-care profiles protocol provided proximal reduce respiratory infections respiratory rate risk Safe SARS-CoV-2 specific effect subject Transmission Viral load VoC VOCs [DOI] 10.1038/s41598-022-22581-7 PMC 바로가기
Emergence and Spread of the SARS-CoV-2 Variant of Concern Delta across Different Brazilian RegionsArticle Published on 2022-10-262022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] affected analysis B.1.617.2 Bayesian method Brazil characteristic clade Cluster Combination Complete concern country COVID-19 COVID-19 pandemic Delta delta variant dissemination distribution dominant variant emergence Epidemic epidemiological Evolution fraction Genome genomic India likelihood Lineage outbreak pandemic Prevalence prevalent profiles Region regions remained Rio de Janeiro SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant spatiotemporal Stage subject Surveillance the SARS-CoV-2 transmission cluster variant Variant of concern. viral variant VoC [DOI] 10.1128/spectrum.02641-21 PMC 바로가기
Lipidomics Revealed Plasma Phospholipid Profile Differences between Deceased and Recovered COVID-19 PatientsArticle Published on 2022-10-152022-11-15 Journal: Biomolecules [Category] 진단, [키워드] abnormality addition analyzed Anemia appear autoantibody changes characterized control group coronavirus COVID-19 COVID-19 patients CRP level Deceased decrease difference disorder disorders FIVE healthy immune system increase in Increased LDH Lipidomics Liver damage low-density Low-density lipoprotein majority Modification oxidative oxidative stress pathophysiological Patient patients Phosphatidylcholine Phosphatidylserine phospholipid Phospholipids plasma plasma. profile profiles Prognostic value recovered recovered patient recovered patients reported Revealed SARS-CoV-2 significantly two subgroup [DOI] 10.3390/biom12101488 PMC 바로가기
Highly perturbed genes and hub genes associated with type 2 diabetes in different tissues of adult humans: a bioinformatics analytic workflowArticle Published on 2022-10-012022-11-16 Journal: Functional & integrative genomics [Category] meta-analysis, [키워드] analysis Apoptosis applied approach association bioinformatics cell type complex defined diabete diabetes Differential gene expression differentially expressed gene downregulated downstream analysis eligible etiology FIVE Gene Expression Gene Expression Omnibus Genes Genetic greater Highly perturbed genes hub gene hub genes identify insulin Kyoto Manifestations marker gene Meta-analysis metabolomics Microarray non-specific ontologies Pathogenesis pathophysiological pathway Pathways Perturbation profiles provided random effect significantly systematic review T2D tissue Type type 2 diabete type 2 diabetes. upregulated utility [DOI] 10.1007/s10142-022-00881-5 PMC 바로가기
Maternal and neonatal immune response to SARS-CoV-2, IgG transplacental transfer and cytokine profileArticle Published on 2022-09-272022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] 229E antibodies antibody Barcelona Blood blood sample C-terminus cause chemokine collected Concentration concentrations COVID-19 cytokine level cytokine levels cytokine profile cytokine response Cytokines distress domain EGF FGF full-length growth factor higher risk HKU1 human coronavirus Humoral response IFN-α IgA level IgG IgM IL-15 IL-17 IL-7 immune response immunological increased risk induce Infection Inflammatory investigated male Maternal maternal and neonatal immunity mother Neonatal Newborn NL63 non-infected nucleocapsid OC43 outcome outcomes positive positive correlation positive for rRT-PCR Pregnancy pregnant women Preterm birth profiles Questionnaires RANTES recruited reduction robust rRT-PCR SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2-specific IgG SARS-CoV-2-specific IgGs serology severe COVID-19 Spain Swab Symptom symptomatic tested transfer transplacental transfer. Vaccines variables was increased were infected were recorded women [DOI] 10.3389/fimmu.2022.999136 PMC 바로가기